- Patient Presentation
- Objectives of Management
- Clinical Approach in Primary Care
- Conservative Treatment for Over Active Bladder
- Pharmacotherapy : Antimuscarinics
- Topical Oestrogen Treatment in Women
- Specialist Management of Over Active Bladder in Secondary care
- Specialist Assessment
- Surgical Treatment for Over Active Bladder (OAB): Botox
- Sacral Neuro-Modulation
- Posterior Tibial Nerve Stimulation
- Bladder Augmentation
- Role of Primary Care Professionals
Patients with Over Active Bladder present with symptoms of Urgency, frequency and nocturia. This may or may not be associated with leakage. This is a common condition and its incidence increases with age in both men and women. In this section we will discuss the etiology, diagnosis and management of this distressing condition.
Conservative management including Lifestyle changes, Bladder retraining and pharmacotherapy plays a major role in the management of this condition. Then we will see the indication for referral to the secondary care.
Over Active Bladder: This is a symptom complex that includes the cardinal symptom of urgency with frequency and nocturia in the absence of any urethral or bladder pathology.
Objectives of Management
- Identify any serious conditions
- Symptom Improvement and alleviate distress
- Systematic approach to treatment in Primary care
- Prompt referral to specialist when appropriate
Clinical Approach in Primary Care
A detailed history about the onset, duration, provoking factors, gynaecological and obstetric history in women.
- Storage symptoms – Urgency, Frequency(daytime& night time) and incontinence
- Voiding symptoms – Hesitancy, intermittency of stream, feeling of inadequate emptying and need to strain
- Look for Red-flag symptoms – Haematuria, painful bladder, loss of weight and appetite
- Clarify the type of incontinence
IPSS (International Prostate Symptom Score) in men. This will help to quantify the symptoms and also assess the voiding symptoms suggestive of prostatic obstruction.
Bladder Diary: Very essential tool to objectively assess the symptoms and helpful to estimate the following parameters
- Daytime and night time frequency
- Volume of urine produced
- Maximum and average bladder capacity
- Quantify the beverage intake
Find a bladder diary in our resources page.
- Abdominal examination to feel any palpable bladder and Pelvic examination to assess for pelvic organ Prolapse and the strength of the pelvic floor.
- In men a digital Rectal Examination (DRE) is mandatory to assess the prostate for benign prostatic enlargement or malignancy.
- Urine Tests: helpful to rule out Haematuria, infection
- Ultrasound scan: helpful to assess the bladder residuals and any other pelvic pathology
- Serum PSA in men: to rule out prostate malignancy and assess the BPH risk
Red flag symptoms & signs
- Palpable Bladder
- Painful Bladder
- Mass, suspected malignancy
- Loss of weight or appetite
- Palpable abnormality in the prostate
- Raised PSA in men
Any of these red-flags should trigger early referral to the urologist.
- Stress Incontinence in women: Typical leakage occurs during coughing, sneezing, effort and exertion. The patients tend to keep the bladder empty before embarking on the activities that is likely to cause leakage. The stress incontinence is caused by excessive movement of urethra (urethral hyper-mobility or urethral sphincter incontinence)
- Urinary Tract Infection: the symptoms will be of short duration and positive growth in culture and appropriate response to antibiotic treatment.
- Painful Bladder: In this condition, the increased frequency is due to bladder pain during the full bladder. The patients visit the toilet frequently to alleviate the pain rather than the fear of leakage.
- Polyuria: certain conditions like diabetes could cause increased production of urine that may be causing the frequency.
- Nocturnal Polyuria: Any condition that causes the swelling of legs like cardiac failure, renal failure may cause increased production of urine at night time due to the mobilisation of fluid from the legs into the circulation. Patients that suffer from sleep apnoea may also have over-production of urine at night time.
- Prostate Diseases: In men prostate diseases need to be ruled out before diagnosing Over Active Bladder.
Conservative Treatment for Over Active Bladder
The non-pharmacological conservative treatment for incontinence can start from day 1 irrespective of type of incontinence.
- Reduce or alter fluid intake : There is no short cut to cure if someone drinks excessive quantities of fluids and bladder stimulants. Tea, Coffee, Fiz etc.
- Timed voiding : This is voiding by clock by pre-set achievable goals
- Losing weight: is likely to improve both stress and urge incontinence
- Smoking cessation
Bladder retraining means to retrain the bladder to hold urine longer and longer to achieve an interval of at least three to four hours between the times of visiting the toilet.
After filling a bladder diary, patients will have a full idea of how frequently they are going to the toilet to urinate. From that interval, for example if they are going to the toilet every two hours, they need to increase the interval by one-half hour increments to achieve a maximum of three to four hours. This needs to be done in increments of one-half hour and once that goal is reached then move on to the next goal.
Pelvic floor Rehabilitation in women
Patients may be referred to a physiotherapist or an incontinence advisor to learn to do pelvic floor exercises. To do the pelvic floor muscle exercise properly, patients need to be taught to identify these muscles. These are the muscles that one would be contracting to stop breaking wind or stop urinating. They will need to contract those muscles in sets of 10 – 20, many times a day to achieve a total of 60 – 80 contractions per day. After mastering the ability to contract these muscles, at the voluntary control patients could contract the pelvic floor muscles before the situations of vulnerability like coughing, laughing and straining that could avoid the leakage. This is called KNACK manoeuvre.
Pharmacotherapy : Antimuscarinics
Antimuscarinics are the mainstay of drug treatment for women with over active bladder symptoms.
Choosing an Anti-muscarinic agent
The choice depends on ease of use, dose flexibility, efficacy and tolerability which varies from patient to patient. NICE guidelines (CG 40) on Incontinence in women recommends starting patients on short acting generic preparations of oxybutynin. It also recommends to counsel the patients about the side effects.
Antimuscarinics in Men with OAB symptoms
Caution is to be exercised before starting men with antimuscarinics. The over active bladder symptoms in men could be caused by prostatic enlargement and therefore appropriate treatment should be given for those conditions if present. For further information on Male Lower urinary symptoms, please click here. If men have predominant voiding symptoms like hesitancy, poor stream and intermittency they should be assessed for prostate problems and antimuscarinics should be avoided and initial treatments with alpha-blockers may be appropriate after full assessment for Male Lower Urinary symptoms.
- Oxybutynin XL (Ditropan XL) 5-30 mg OD
- Oxybutynin 2.5mg – 5mg TID
- Oxybutynin Dermal – 3.9mg twice weekly
- Trospium Chloride – 20mg bd – Half life 20 hours – Does not cross BBB
- Tolterodine 1-2mg PO BID – Half life 10 hours
- Fesoterodine 4mg, 8mg – Half life 8 hours
- Solifenacin 5mg,10mg – Half life 50 hours
- Darifenacin 7.5mg, 15mg – Half life 20 hours
- Dryness of mouth and eyes: need to drink more fluids that could be counter-productive
- Cardio-Vascular side effects
- Gastrointestinal side effects – indigestion, constipation
- Cognitive side effects : sedation and cognitive disturbances
Topical Oestrogen Treatment in Women
It is not clear, how the topical oestrogen help in incontinence. They are proven to improve urge incontinence. Risks: Though the systemic absorption is very small, patients should be informed about the uncertainty about the risks. This should be avoided in patients taking anti-oestrogen treatment for breast cancer.
How does it work?
The following mechanisms were postulated for the benefits from topical oestrogens.
- Increased Urethral closing pressure
- Raises sensory threshold in the bladder
- Makes vaginal epithelium more Healthy & Defensive
- Increases sensitivity and number of alpha receptors
Vildrup L et al, Current Med Res opin,19:485-490,2003
Specialist Management of Over Active Bladder in Secondary care
If patients do not get adequate benefit from conservative treatment or if there are any serious conditions or other curable urological conditions causing the symptoms, they will need referral to an urologist.
If the incontinence is accompanied by pelvic organ Prolapse, they will benefit from a referral to an urogynaecologist.
Full conservative treatment: If patients have not received full counselling about lifestyle changes and bladder retraining, they will go on to try these treatments under specialist’s care.
Diagnostic Cystoscopy : This may be necessary if there are any suspicion about bladder pathology.
Urodynamic Study: This test will be considered prior to any surgical intervention to assess the function of the bladder.
This involves passing a fine catheter into the bladder and another fine line through the anus into the lower part of the bowel. These fine lines will have electronic pressure sensors (transducers). When the bladder is filled with water, these fine lines will measure the pressures inside the bladder, as well as in the abdomen. During the bladder filling, any contraction of the bladder muscle (detrusor) if associated with symptoms of urgency, that will diagnose Detrusor Overactivity. It is also possible to demonstrate the stress leaks by making patients to cough and do valsalva manoeuvre, and the pressure in the abdomen at which the leakage occurs is measured. This test is a reliable way of differentiating different components of incontinence in women particularly when patients present with mixed symptoms. In men, Urodynamic study will be helpful to confirm or rule out Bladder outlet obstruction.
Surgical Treatment for Over Active Bladder (OAB)
Botox Injection into the Bladder:
Botox injection of the bladder is useful to treat overactive bladder (both idiopathic overactive bladder and overactive bladder secondary to other neurological diseases). Botox is a highly potent toxin known to man and is produced by a bacterium called Clostridium Botulinum. This is a very potent muscle relaxant and injecting this toxin in very minute quantities in the bladder muscle helps to relax to bladder muscle and increases the capacity to hold urine. When patients are diagnosed with bladder over activity, Botox injections do help and result a substantial improvement of their symptoms. The use of Botox for other conditions in cosmetic surgery and as well as in muscle spasms in the other parts of the body is well established. Botox works by blocking the nerve fibres in the muscle thereby preventing the muscle contractions in the part where the Botox is injected. Botox injection into the bladder is a fairly recent method of treatment and it has been in practice just over ten years. However when over activity of the bladder is treated with Botox injections the results are about 70-80% improvement in incontinence and reduction in the frequency. The improvement after the Botox injection lasts for about six months. After this the Botox effects do wear off and it is necessary to repeat the injections of Botox.
How is Botox injected into the bladder?
The Botox is a powder preparation which is reconstituted with by adding in fluid which is used as an injection. It is injected through a special needle which is passed down an instrument called a cystoscope. This can be done under either local anaesthetic or general anaesthetic. The entire procedure can take from 15 to 20 minutes.
What are the long term effects of Botox?
Since the Botox treatment has been in practice for only the past ten years, it is difficult to predict the long term consequences of injecting Botox into the bladder. Therefore urologists are cautious about using this method of treatment for very young patients with a long life expectancy. Since Botox treatments need to be repeated on regular interval to achieve the ongoing control of the symptoms, it is a concern for urologists and patients alike with regard to long term effect on the bladder function.
What is Sacral Neuro-modulation?
This is a special type of treatment which is useful to re-establish the normal bladder function. This is done by applying electrical stimulation to the nerves of the sacral spinal cord level that controls the bladder.
What conditions are treatable with Sacral Neuro-modulation?
Sacral Neuro-modulation is used to treat the following:
Non-obstructive urinary retention (female urinary retention). This is a condition where women find it impossible to pass urine due to blockage at the level of the urethra without any obvious blockage.
Overactive bladder with the typical symptoms of urgency and frequency with a bit of urge incontinence.
What is involved in this treatment?
The Sacral Neuro-modulation is done by a device called Intestim which generates a pulse. This is done in two phases. In the first phase, which is called test phase, a temporary electrode is inserted into the sacral spine touching the S2/S3 nerves. Then the electrodes are connected to a temporary nerve stimulator device. Patients will be assessed for a few weeks with this device to see if this enables them to better control their bladder or improves their urinary retention. If the temporary device is effective, then they would move onto the second phase of implanting the permanent device which would be implanted in the buttocks and connected to the electrodes. Recently the electrodes which are used for the test phase are permanent electrodes though they are connected to the temporary device. This avoids the insertion of the second electrode into the spinal canal.
How effective is this treatment?
This treatment is effective in the range of 70-80% of those treated for retention. More than 70% of the patients can be rendered catheter free or they can be made free of having to use self catheterisation. With regard to overactive bladder symptoms, the success rates are about 70%. This treatment is uniquely different from Botox or other treatment because this neural modulation treatment helps to re-establish the bladder function. This is an appropriate treatment method for a group of patients who respond favourably to the test phase treatment.
Posterior Tibial Nerve Stimulation
Posterior tibial nerve stimulation is a non-invasive method of achieving better bladder control. The nerve endings in the leg are stimulated by using the nerve stimulator which is a small gadget attached to very tiny needle electrodes that are inserted in the skin of the lower leg and in the hind foot. Stimulating the sensitive nerves in this area does give better control of the bladder by its action at the spinal root level. After placing the needle electrode through two pads which are applied just above the ankle and near the hind foot which is connected to the small gadget device (called a pulse generator), the entire treatment takes about 30 minutes. This treatment is repeated on a weekly basis for twelve weeks. PTNS does not have any significant side effects. It is a fairly less risky procedure. The minor side effects are irritation from the pads or from the needles. This may include minor skin irritation. There are a few studies which effectiveness of this treatment. Overall the results are broadly similar with 70-80% of patients showing some improvement in their overactive bladder symptoms.
This is offered for patients with extreme symptoms of overactive bladder with diminished bladder capacity. This involves taking a piece of small bowel and put it as a patch to increase the capacity of the bladder. This involves a major operation and the after effects may include the need to use self catheterisation and problems with mucous secretion from the bowel segment. Over the long term there is slightly increased risk of malignancy and therefore regular surveillance cystoscopy is necessary.
Role of Primary Care Professionals
Start Conservative Treatment from Day 1 after ruling out
- Red flag signs and other correctable conditions
Secondary Care referral at appropriate stage
- Any Red flag signs or other urological conditions – Urologist
- Men with OAB symptoms and suspected prostate pathology – Urologist
- Women with Urge & Stress Incontinence – Urologist or Uro-gynaecologist
- Women with Associated pelvic Organ prolapse – Uro-gynaecologist
Periodic Follow up – Every 6 to 8 weeks
- To Motivate
- To change the drug treatment as necessary
- Expedite Secondary Care Treatment
Proactive planning for
- Treatment escalation